Toshihiko Yada Selected Research

AIDS-Related Complex (ARC)

12/2022	D-Allulose cooperates with glucagon-like peptide-1 and activates proopiomelanocortin neurons in the arcuate nucleus and central injection inhibits feeding in mice.
6/2022	TRPV1-Mediated Sensing of Sodium and Osmotic Pressure in POMC Neurons in the Arcuate Nucleus of the Hypothalamus.
10/2021	Onion component, isoalliin, stimulates feeding and activates the arcuate nucleus neuropeptide Y, ghrelin- and Ninjin'yoeito-responsive neurons.
1/2020	Ninjin'yoeito Targets Distinct Ca2+ Channels to Activate Ghrelin-Responsive vs. Unresponsive NPY Neurons in the Arcuate Nucleus.
6/2019	Ninjin-yoeito activates ghrelin-responsive and unresponsive NPY neurons in the arcuate nucleus and counteracts cisplatin-induced anorexia.
12/2018	Protective role of AgRP neuron's PDK1 against salt-induced hypertension.
11/2018	New insight into GABAergic neurons in the hypothalamic feeding regulation.
1/2018	GLP-1 receptor agonist liraglutide exerts central action to induce β-cell proliferation through medulla to vagal pathway in mice.
10/2017	Adiponectin at physiological level glucose-independently enhances inhibitory postsynaptic current onto NPY neurons in the hypothalamic arcuate nucleus.
4/2017	AAV-mediated IL-10 gene transfer counteracts inflammation in the hypothalamic arcuate nucleus and obesity induced by high-fat diet.

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Toshihiko Yada Research Topics

Disease

31	AIDS-Related Complex (ARC) 12/2022 - 04/2003
19	Obesity 12/2022 - 12/2005
15	Body Weight (Weight, Body) 01/2020 - 01/2008
14	Type 2 Diabetes Mellitus (MODY) 01/2019 - 12/2004
9	Anorexia 10/2021 - 11/2009
8	Insulin Resistance 01/2021 - 02/2007
7	Hyperphagia (Overeating) 01/2018 - 12/2008
5	Hyperglycemia 01/2018 - 04/2004
5	Glucose Intolerance 01/2018 - 12/2006
4	Hypertension (High Blood Pressure) 06/2022 - 01/2013
4	Neoplasms (Cancer) 10/2021 - 04/2011
4	Metabolic Syndrome (Dysmetabolic Syndrome X) 10/2017 - 01/2007
2	Abdominal Obesity 01/2018 - 01/2013
2	Schizophrenia (Dementia Praecox) 01/2018 - 04/2014
2	Atherosclerosis 10/2017 - 01/2016
2	Inflammation (Inflammations) 04/2017 - 08/2002
2	Starvation 09/2015 - 04/2012
2	Chronic Obstructive Pulmonary Disease (COPD) 05/2015 - 03/2015
2	Weight Loss (Weight Reduction) 11/2014 - 04/2011
2	Hyperinsulinism (Hyperinsulinemia) 01/2014 - 01/2013
2	Insulinoma 10/2005 - 05/2002
1	Frailty 06/2019
1	Heart Failure 06/2019
1	Sarcopenia 06/2019
1	Parkinson Disease (Parkinson's Disease) 09/2017
1	Nervous System Diseases (Neurological Disorders) 09/2017
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 07/2016
1	Stomach Neoplasms (Stomach Cancer) 05/2016
1	Hypersensitivity (Allergy) 01/2016

Drug/Important Bio-Agent (IBA)

24	GhrelinIBA 10/2021 - 04/2003
23	Glucose (Dextrose)FDA LinkGeneric 12/2022 - 03/2004
16	Insulin (Novolin)FDA Link 01/2017 - 04/2004
14	Neuropeptide YIBA 01/2020 - 04/2003
13	Pro-Opiomelanocortin (Proopiomelanocortin)IBA 12/2022 - 09/2003
11	LeptinIBA 04/2017 - 09/2003
10	Fura-2 (Fura 2)IBA 12/2022 - 04/2003
8	Glucagon-Like Peptide 1 (GLP 1)IBA 12/2022 - 06/2009
7	Peptides (Polypeptides)IBA 06/2022 - 04/2003
7	Oxytocin (Pitocin)FDA LinkGeneric 07/2018 - 11/2009
6	Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)IBA 01/2016 - 08/2002
5	Dihydrotachysterol (AT 10)IBA 01/2018 - 03/2005
4	Appetite Depressants (Anorectics)IBA 01/2020 - 01/2012
4	Messenger RNA (mRNA)IBA 01/2017 - 05/2013
3	SaltsIBA 06/2022 - 01/2013
3	Cisplatin (Platino)FDA LinkGeneric 10/2021 - 06/2019
3	ninjin'yoeitoIBA 10/2021 - 06/2019
3	LipidsIBA 01/2020 - 05/2008
3	Adenosine Triphosphate (ATP)IBA 08/2015 - 05/2002
3	NeuropeptidesIBA 01/2012 - 04/2006
3	Galanin-Like PeptideIBA 04/2006 - 02/2005
2	psicose (D-psicose)IBA 12/2022 - 01/2018
2	MelanocortinsIBA 06/2022 - 11/2009
2	Pharmaceutical PreparationsIBA 10/2021 - 06/2019
2	CatecholaminesIBA 01/2019 - 12/2009
2	Dimenhydrinate (DMH)FDA LinkGeneric 11/2018 - 08/2016
2	gamma-Aminobutyric Acid (GABA)IBA 11/2018 - 06/2005
2	AdiponectinIBA 10/2017 - 01/2016
2	Hormones (Hormone)IBA 01/2017 - 02/2008
2	Blood Glucose (Blood Sugar)IBA 07/2016 - 11/2004
2	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2016 - 10/2005
2	SmokeIBA 05/2015 - 03/2015
2	Serotonin (5 Hydroxytryptamine)IBA 08/2013 - 01/2012
2	liu-jun-zi-tangIBA 08/2013 - 01/2012
2	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2013 - 01/2012
2	AICA ribonucleotide (ZMP)IBA 07/2011 - 02/2008
2	OrexinsIBA 11/2008 - 03/2004
2	AdipokinesIBA 05/2008 - 02/2007
2	ResistinIBA 05/2008 - 02/2007
1	ElectrolytesIBA 06/2022
1	alliin (PCSO)IBA 10/2021
1	CRF receptor type 2IBA 12/2019
1	UrocortinsIBA 12/2019
1	Cytotoxins (Cytolysins)IBA 12/2019
1	Liraglutide FDA Link 01/2019
1	Glucagon-Like Peptide-1 ReceptorIBA 01/2019
1	HydrogenIBA 09/2017
1	Interleukin-10 (Interleukin 10)IBA 04/2017
1	CytokinesIBA 04/2017
1	Phosphotransferases (Kinase)IBA 04/2017
1	Epinephrine (Adrenaline)FDA LinkGeneric 01/2017
1	fibroblast growth factor 21IBA 01/2017
1	Insulin-Like Growth Factor I (IGF-1)IBA 01/2017
1	Sodium-Glucose Transporter 2 InhibitorsIBA 07/2016
1	Angiopoietin-Like Protein 8IBA 07/2016
1	Streptozocin (Streptozotocin)FDA Link 07/2016
1	Hypoglycemic Agents (Hypoglycemics)IBA 01/2016
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2016
1	trichlorosucrose (sucralose)IBA 01/2016
1	Type I Vasoactive Intestinal Polypeptide ReceptorsIBA 01/2016
1	Sweetening Agents (Sweeteners)IBA 01/2016
1	Serine (L-Serine)FDA Link 09/2015
1	Ouabain (G Strophanthin)IBA 08/2015
1	Agouti-Related ProteinIBA 08/2015

Therapy/Procedure

3	Kampo Medicine (Kampo) 10/2021 - 06/2019
3	Gastrectomy 05/2016 - 01/2010
2	Glycemic Control 01/2015 - 12/2006
1	Subcutaneous Infusions 11/2019
1	Oral Administration 06/2019
1	Pancreatectomy 07/2016
1	Adjuvant Chemotherapy 05/2016